Use "nginx -t" to debug nginx issues. It's a known issue when nginx fails to start in Vesta due to some misconfiguation occurred by itself. nginx: [emerg] the same path name "/var/cache/nginx/xxx.es" used in /etc/nginx/conf.d/01_caching_pool.conf:2 and in /etc/nginx/conf.d/01_caching_pool.conf:3 nginx: configuration file /etc/nginx/nginx.conf test failed nginx: [emerg] the same path name "/var/cache/nginx/xxx.es" used in /etc/nginx/conf.d/01_caching_pool.conf:2 and in /etc/nginx/conf.d/01_caching_pool.conf:3 nginx: configuration file /etc/nginx/nginx.conf test failed [root@server ~]# cat /etc/nginx/conf.d/01_caching_pool.conf proxy_cache_path /var/cache/nginx/xxx.com levels=2 keys_zone=xxx.com:10m inactive=60m max_size=512m; proxy_cache_path /var/cache/nginx/xxx.es levels=2 keys_zone=xxx.es:10m inactive=60m max_size=512m; remove all the duplicate lines. And then restart nginx.