Generally, a properly tuned Nginx server on Linux can handle 500,000 - 600,000 requests per second. My Nginx servers consistently handle 904k req/sec, and have sustained high loads like these for the ~12 hours that I tested them.
It's important to know that everything listed here was used in a testing environment, and that you might actually want very different settings for your production servers.
Install the Nginx package from the EPEL repository or use existing web panels with nginx stack.
Back up the original nginx.conf config file, and start hacking away at a config of your own.